A recent study suggests that people who discontinue new weight-loss injections like Wegovy and Mounjaro tend to recover lost weight much more quickly than those who end traditional lifestyle programs.
Findings released in a leading health publication points out that while overweight people can lose substantial amounts of their total mass while on the medication, the mass returns at an average rate of 0.8 kg per month upon discontinuation.
"Users purchasing these treatments must be informed of the risk of rapid rebound weight gain when the therapy is stopped," warns researcher Dr. Susan Jebb.
This pace of regain suggests a reversion to starting weight in about one and a half years.
Analyzing Treatments
The study, which looked at 37 of trials involving thousands of participants, compared the outcomes of the injectable medications with other pills.
Scientists note that individuals who shed pounds through dieting typically experience a less rapid creep back—approximately 0.1 kg a month—once they finish.
The Reason for the Fast Rebound
Experts propose the way of the injections explains the amplified regain.
These medications mimic a natural hormone called GLP-1, which controls appetite.
"Sustained high doses of the hormone levels far above than the body's typical production might result in the system to generate a reduced amount of its endogenous hormone, and may also lessen responsiveness to its effects," said Dr. Adam Collins, a nutrition specialist.
"Withdrawal of this medication leads to hunger is no longer kept in check, making overeating much more probable."
A Chronic Issue?
The NHS recommend the jabs for people with obesity-related medical conditions, alongside recommended diet and exercise modifications.
Many experts contend that, considering the likelihood of weight regain, the treatment is often life-long.
This view is echoed by pharmaceutical companies, who state that the findings "underscore the chronic nature of obesity," akin to managing conditions like high blood pressure.
User Accounts
People who have come off the medication describe a sudden resurgence of cravings.
"It was like something that goes on and you become ravenous," recalled an individual.
This challenge is compounded if individuals have not developed permanent lifestyle or habit modifications during treatment.
Significant Interest
Survey data suggest that millions of adults in the UK have tried these injections in the last 12 months, with desire continuing to grow.
- Adoption is greater among women compared to men.
- The middle-aged age group shows the greatest level of interest.
- A large proportion access the medications through private healthcare rather than the NHS.
In conclusion, researchers emphasize that while the jabs are effective agents for weight loss, they are not a magic cure and long-term success relies on ongoing lifestyle support.
